Injecting the Power of AI! Status Creation at the First Synthetic Biology Science and Technology Skincare Summit

Synthetic biotechnology was once known as the beauty industry's "new energy", how to continue to break new ground?

September 11, by the beauty headlines, CBE Hangzhou International Beauty Expo co-sponsored by the raw materials door, product managers club co-organized "research up" 2024 first synthetic bioscience skincare summit forum in Hangzhou, Zhejiang Province, a successful conclusion.

Stimulus Bio was invited to participate in the conference, won the "Synthetic Biotechnology Innovative Ingredients Award", and delivered a keynote speech on "AI+BIO: How Synthetic Biotechnology Builds Pure Micro-ecological Skincare", exploring the potential new opportunities for the cosmetic industry under the synthetic biology with the partners in the beauty industry. with the beauty industry partners to explore the potential new opportunities for the cosmetics industry under synthetic biology.

According to the "micro-ecological skin care market consumer insights" of the Beauty Industry Institute, as consumers pay more and more attention to product safety, environmental protection and no additives, the concept of micro-ecological skin care has accelerated its popularity in China. E-commerce data show that in the first half of this year, "micro-ecological fermentation" related product sales trend is all the way up.

In fact, 80%'s skin sensitivity problem stems from a damaged barrier caused by an imbalance in the flora. Micro-ecological skin care is precisely through the active ingredients of skin care products to promote the growth of beneficial bacteria, inhibit the reduction of harmful bacteria, help the skin to maintain the balance of the microbiome, and improve the health of the skin.

The common micro-ecological skin care efficacy ingredients on the market are categorized into three main types: probiotics, prebiotics and postbiotics. These ingredients play an important role in a number of skincare star products such as Shiseido SKII, Estee Lauder Big Brown Bottle, Lancôme Little Black Bottle and so on. Among them, probiotics and postbiotics involve fermentation technology, and both are also important supports for fermented skincare.

The development of the micro-ecological skin care market shows strong growth momentum and market potential. According to a report by the Beauty Industry Institute, the market is expected to reach $10.54 billion by 2025.

Specifically in the field of fermentation in micro-ecological skincare, both probiotics and postbiotics place high demands on the performance of the strains, as this is directly linked to the safety and functionality of the final skincare product.

In response, the Ecotron research team utilized the AI active peptide prediction mining model TIDETRON COMDEL®The company has been able to obtain high-performance Lactobacillus mutants through targeted evolution and high-throughput screening technologies to facilitate micro-ecological skincare ingredient innovations.

First, the genomes, transcriptomes and proteomes of 114 edible probiotic species were collected and utilized in the AI active peptide prediction mining model TIDETRON COMDEL®From these, Lactobacillus strains with the strongest ability to inhibit harmful bacteria were screened.

Next, the high-yielding strains were subjected to directed evolution using a multi-combination mutagenesis system and screened for final high-performance Lactobacillus mutants by fluorescence-activated droplet sorting (FADS) technology. The strains obtained by mutagenesis had a 2-3-fold enhancement in bacteriostatic capacity, which was significantly better than that of naturally isolated strains.

Lactobacillus fermentation products based on this high-performance strain have been experimentally verified to exhibit excellent potential in soothing and stabilizing, oil and acne control, moisturizing and antioxidant properties.

In fact, not only micro-ecological skincare, from anti-aging ingredients mining to improve the efficacy of dark circles, AI technology in the field of science and technology skincare application has become a trend.

Accordingly, in addition to the AI active peptide prediction mining model TIDETRON COMDEL®In addition, Staxtron has also developed innovative ingredients such as collagen and arachnid protein by combining cutting-edge AI technologies such as ProteinMPNN and AlphaFold2.

At present, Stage Creation has built a pure skin care raw material system, covering more than 30 kinds of high-purity and high-activity green skin care raw materials. At the same time, the AI+BIO platform is open to the public, providing functional raw material customization, process upgrading customization, joint technology research and development services, looking forward to the supply of raw materials and technological innovation to empower the beauty industry partners, and work together towards a new era of scientific and technological skincare.

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